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Int J Oral Biol. 2014 Mar;39(1):1-7. Korean. Original Article.
Park HJ , Jeon JH , Kim MK , Ryu MH , Kim YD , Bae SK , Bae MK .
Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan 626-870, South Korea. mkbae@pusan.ac.kr
Department of Dental Pharmacology, School of Dentistry, Pusan National University, Yangsan 626-870, South Korea.
Department of Oral Pathology, School of Dentistry, Pusan National University, Yangsan 626-870, South Korea.
Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University, Yangsan 626-870, South Korea.
Abstract

Neuromedin B (NMB) acts as a growth factor or a morphogen and plays a role in cancer progression. Indeed, the NMB receptor (NMB-R) is overexpressed in different types of tumors. In our current study, we investigated the involvement of NMB-R in the proliferation of oral cancer cells. Human oral squamous cell carcinoma (SCC) and human oral cancer cells, SCC-25 cells were found to be NMB-R-positive. The NMB-R antagonist PD168368 inhibited the proliferation of SCC-25 cells and reduced their colony formation capacity. We also found that PD168368 induced the cell cycle arrest and apoptosis of SCC-25 cells in a dose-/time-dependent manner. Overall, this antitumor activity of PD168368 in human oral cancer cells suggests that NMB-R is a potential target for the future prevention and treatment of human cancers.

Copyright © 2019. Korean Association of Medical Journal Editors.