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J Korean Bone Joint Tumor Soc. 2012 Jun;18(1):14-19. Korean. Original Article. https://doi.org/10.5292/jkbjts.2012.18.1.14
Kong CB , Hong YS , Lee KY , Cho SH , Song WS , Cho WH , Koh JS , Jeon DG .
Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea. wssongmd@gmail.com
Department of Pathology, Korea Cancer Center Hospital, Seoul, Korea.
Abstract

PURPOSE: We analyzed the oncologic outcome of the malignant transformed benign giant cell tumor of bone. MATERIALS AND METHODS: Between January 2000 and February 2012, 5 cases were referred with suspicious malignant transformation of benign giant cell tumor. No patients underwent radiation therapy. RESULTS: After referral, all patients received the wide excision of the tumor and its' pathologic diagnosis were osteosarcoma. As classified by the location of tumor lesion, 3 cases were located in the distal femur, 1 case was in the distal radius and 1 case was in the proximal femur. The average latent period between diagnosis of benign giant cell tumor and diagnosis of secondary malignant giant cell tumor was 49.2 months. (range, 24-126 months) The mean follow-up period was 21.6 months. There were subsequent local recurrence in 2 cases and 3 patients developed distant metastasis. All patients with lung metastasis were dead. CONCLUSION: Malignant transformation of benign giant cell tumor of bone can be occurred within 5 years. Therefore, when benign giant cell tumor suspicious malignant transformation, it is necessary to do more aggressive treatment.

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