PURPOSE: In dental clinical fields, various periodontal membranes are currently used for periodontal regeneration. The periodontal membranes are categorized into two basic types: resorbable and non-resorbable. According to the case, clinician select which membrane is used. Comparing different membranes that are generally used in clinic is meaningful. For this purpose, this study evaluates histological effects of various membranes in canine one wall intrabony defect models and it suggest a valuation basis about study model. MATERIAL AND METHOD: The membranes were non-resorbable TefGen Plus(R), resorbable Gore Resolut XT(R) and resorbable Osteoguide(R). One wall intrabony defects were surgically created at the second and the mesial aspect of the fourth mandibular premolars in either right or left jaw quadrants in two dogs. The animals were euthanized 8 weeks post-surgery when block sections of the defect sites were collected and prepared for histological evaluation. RESULTS: 1. While infiltration of inflammatory cells were observed in control, TefGen Plus(R) and Gore Resolut XT(R), it was not observed in Osteoguide(R). 2. TefGen Plus(R) had higher integrity than others and Osteoguide(R) was absorbed with folding shape. Gore Resolut XT(R) was divided everal parts during resorbtion and it was also absorbed from inside. 3. Quantity of new bone and new cementum was not abundant in all membranes. 4. For histologic evaluation of membranes we should consider infiltration of inflammatory, migration of junctional epithelium, integrity of membrane, quantity of new bone and new cementum, connective tissue formation and aspect of resorption. CONCLUSION: This histologic evaluation suggests that Osteoguide(R) provides periodontal regenerative environment with less inflammatory state. It is meangful that this study model suggests a valuation basis about other study model.