Cushing's disease can cause obesity, diabetes and hypertension. Nephrolithiasis is prevalent in obese population. A variety of factors influence the formation of nephrolithiasis such as gender, diet, and urinary excretion of calcium, oxalate, and uric acid. We report a case of Cushing's disease in an obese diabetic patient accompanied by recurrent urinary tract infection and nephrolithiasis. After the removal of pituitary tumor, diabetes and urinary tract infection were completely remitted.