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Korean J Obes. 2009 Dec;18(4):158-166. Korean. Original Article.
Lee HJ , Yun KE , Park HS , Kim SM , Choi KM .
Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Korea.
Department of Family Medicine, Korea University College of Medicine, Korea.
Devision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Korea.

BACKGROUND: C-reactive protein and adipokines are associated with obesity and insulin resistance. The relations between C-reactive protein, adipokines and metabolic risk factors have been extensively studied in adults, but there are no comparable data in pre-pubertal children. We investigated the associations between C-reactive protein, several adipokines and metabolic risk factors in pre-pubertal Korean children. METHODS: A total of 324 pre-pubertal children (149 boys and 175 girls) aged 8~9 years were evaluated for height, weight, blood pressure and body mass index (BMI). The serum hs-CRP, adiponectin, TNF-alpha, vaspin, RBP4, fasting glucose, insulin, lipid profile were also measured. Overweight was defined as being at or above the 85th percentile of the gender-specific BMI for age in the 2007 Korean National Growth Chart. RESULTS: In boys, serum hs-CRP levels were correlated with BMI (r = 0.339, P < 0.001), waist circumference (r=0.356, P<0.001), systolic blood pressure (r = 0.183, P < 0.05), diastolic blood pressure (r = 0.168, P < 0.05), ALT (r = 0.311, P < 0.001), insulin (r = 0.226, P < 0.05) and HOMA-IR (r = 0.199, P < 0.05). In girls, serum hs-CRP levels were correlated with BMI (r = 0.332, P < 0.001), waist circumference (r = 0.311, P < 0.001), Triglycerides (r = 0.177, P < 0.05), HDL-C (r = -0.232, P < 0.001), ALT (r = 0.152, P < 0.05), insulin (r = 0.238, P < 0.01), HOMA-IR (r = 0.233, P < 0.01). Serum adiponectin levels were negatively correlated with ALT and AST in boys and total cholesterol levels in girls, respectively. There was no correlation between serum TNF-alpha, vaspin, RBP4 levels and metabolic risk factors in boys. In girls, serum fasting glucose levels was negatively correlated with serum TNF-alpha levels, and positively correlated with serum vaspin levels. In multiple linear regression analysis, body mass index was best predictor of hs-CRP in boys and girls. CONCLUSION: Serum hs-CRP was significantly associated with BMI, waist circumference and other metabolic risk factors in pre-pubertal children. Among these metabolic risk factors, BMI was the best predictor of hs-CRP concentration in both boys and girls. A larger study might be helpful to characterize the relationship between metabolic risk factors and inflammatory markers in this age group.

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