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Korean J Nosocomial Infect Control. 2013 Dec;18(2):44-50. Korean. Original Article. https://doi.org/10.14192/kjnic.2013.18.2.44
Jun KI , Koo HL , Kim MK , Kang CK , Kim MJ , Chun SH , Song JS , Kim HS , Kim NJ , Kim EC , Oh MD .
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. molder@unitel.co.kr
Infection Control Service, Seoul National University Hospital, Seoul, Korea.
Department of Pharmacy, Seoul National University Hospital, Seoul, Korea.
Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
Abstract

BACKGROUND: The aim of this study was to evaluate antibiotic consumption by adult patients at a single university hospital in Korea between 2001 and 2012. METHODS: We used the 2004 World Health Organization Anatomical Therapeutic Chemical Classification System definition of defined daily doses (DDD) per 1,000 patient-days to calculate the annual antibiotic consumption for 18 antibiotic groups. Chi-square linear-by-linear analysis was performed to evaluate antibiotic consumption trends for each group. RESULTS: Average annual antibiotic consumption during 2001-2012 was 644.6 DDD/1,000 patient-days (standard deviation, 33.3 DDD/1,000 patient-days). Although no statistically significant change was observed during the study period, consumption of first- and second-generation cephalosporins, and aminoglycosides was significantly decreased, while that of beta-lactam/beta-lactamase inhibitors, fourth-generation cephalosporins, carbapenem, glycopeptide, linezolid, colistin, and quinolone increased significantly. CONCLUSION: The total amount of prescribed antibiotics did not change, but the use of broad-spectrum antibiotics increased during the study period.

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