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Korean J Biol Psychiatry. 2012 Feb;19(1):53-57. Korean. Original Article.
Kim TS , Cha SM , Wang SK , Kim JL , Lee YH , Choi HI , Chee IS .
Department of Psychiatry, Chungnam National University Hospital, Daejeon, Korea.
Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, Korea.
Department of Anatomy, School of Medicine, Chungnam National University, Daejeon, Korea.

OBJECTIVES: This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia. METHODS: TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls. RESULTS: There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls. CONCLUSIONS: These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.

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