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Korean J Biol Psychiatry. 2012 Feb;19(1):53-57. Korean. Original Article.
Kim TS , Cha SM , Wang SK , Kim JL , Lee YH , Choi HI , Chee IS .
Department of Psychiatry, Chungnam National University Hospital, Daejeon, Korea.
Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, Korea. ischee@cnu.ac.kr
Department of Anatomy, School of Medicine, Chungnam National University, Daejeon, Korea.
Abstract

OBJECTIVES: This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia. METHODS: TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls. RESULTS: There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls. CONCLUSIONS: These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.

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