The purpose in this study is to make a regression model for the prediction of skeletal muscle volume in thigh. For this purpose, men,14 and women,6 were included in this study. They were measured 22 independent variables by CT and anthropometry methods. CT Image analysis were performed with INFINITT, Rapidia 2.8, Korea. The results in this study are as following. There were not significant (P=.000) between CT-measured variables and predicted variables by anthropometry, excepting the difference (P=0.01) at thigh top muscle circumference. Therefore, many of variables could be applied with parameters for estimation equation by anthropometry. The estimation equation, obtained for thigh muscle volume using the predicted mid-thigh muscle circumference corrected by skinfold thickness and predicted total femur bone volume, was Y(Mtot)=127.4134x(X1)+18.7767x(X2)-5998.62. Where, X1 is predicted mid-thigh muscle circumference and X2 is predicted total femur bone volume. R2 in this model is .97, and SEE is 123 mL, CV 3.6%. In conclusion, the determination of skeletal muscle volume in thigh can be highly validated with estimaton model in this study. Therefore it also be apply to predicting thigh muscle volume in korean adults.