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Korean J Clin Microbiol. 2008 Oct;11(2):136-140. Korean. Case Report.
Oh HR , Kim YS , Jang SJ , Li XM , Kim WY , Park G , Moon DS , Park YJ .
Department of Laboratory Medicine, Chosun University Medical School, Gwangju, Korea.
Department of Radiology, Chosun University Medical School, Gwangju, Korea.
Department of Research Center for Resistant Cells, Chosun University Medical School, Gwangju, Korea.
Department of Microbiology, Chungang University Medical, Seoul, Korea.

Nocardia cyriacigeorgica is an aerobic gram-positive rod that has mostly been reported as an opportunistic pathogen. Since molecular methodologies were introduced to identify species, infections caused by N. cyriacigeorgica have been reported. The patient was a 51-year-old woman with aplastic anemia, systemic lupus erythematosus, and disseminated tuberculosis, who was admitted to Chosun University Hospital with a history of fever and productive cough. During her hospitalization, sputum cultures were taken and a bacterium suspicious of acitinomycetes grew five times. It was a gram-positive rod that was also partially acid-fast on modified Kinyoun stain and resistant to lysozyme. After 24 h of incubation, cultures of the sputum onto sheep's blood agar plates (BAP) demonstrated rough, chalky, and white colonies with a characteristic earthy odor. Based on the above results, the presumptive identification of Nocardia species was made. To identify species of this isolate, 16S rRNA gene sequence analysis was taken and showed 99.9% homology to N. cyriacigeorgica DSM44484(T). The results of biochemical tests were compatible with other reports of N. cyriacigeorgica. As a result, this isolate was identified as N. cyriacigeorgica. Herein, we present a first report of N. cyriacigeorgica isolated from a patient with pulmonary infection in Korea.

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