Reversible lesion in the splenium of the corpus callosum can be caused by various conditions. There is no report about the case with first seizure attack. We report a 25-year-old man shown transient isolated splenial lesion of the corpus callosum associated with new onset seizure. Lesion was shown in the splenium of the corpus callosum on MRI. Theses findings were resolved on follow up MRI without specific treatment. This case suggests that the first attack seizure could make a reversible splenial lesion.