There have been many difficult cases in direct closure of soft tissue defect of frontal area because of its tension, so that for reconstruction of this area skin graft, local flap and free flap has been used traditionally. Although local flap represent best result in concern of its color, touchness and compatability of function, it is not always available in case that the defect size is wide. we must consider skin graft in such case but it also can not be used if there is exposure of bone with loss of periosteum. Recently there are many reports about the use of collagen dermal substitude (Terudermis(R)) and the use of Hydrogel(R) which provide moist wound environment to facilitate epithelization is increased. The authors report the experience of combination treatment with Terudermis(R) and Hydrogel(R) to take rapid soft tissue regeneration in case of wide soft tissue defect in frontal area with bone exposure.