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J Korean Cleft Palate-Craniofac Assoc. 2001 Oct;2(2):147-150. Korean. Original Article.
Yoon DJ , Hwang SM , Bae YC .
Department of Plastic and Reconstructive Surgery, College of Medicine, Pusan National University, Pusan, Korea.

Kimura's disease is a rare chronic inflammatory condition characterized by proliferation of vascular endothelial cells, lymphoid infiltration, and mixed inflammatory cells infiltrated with numerous eosinophils. That was known in Western literature as angiolymphoid hyperplasia with eosinophilia and many reports have used the terms synonymously. But the histological features between the 2 disorders have been proved to be distinctive and the 2 terms should not be used synonymously. A case of huge sized(24x12x10cm) Kimura's disease, the patient was 20-year-old male who has painless soft mass on his right cheek. Preoperatively, proteinuria(2+), serum eosinophilia(27.7%), increased serum Ig E(above 2500 IU) were noted in laboratory tests. Histologically, mixed inflammatory cells infiltrated with numerous eosinophils and reactive lymphoid follicles with germinal center were observed, and the proliferation of typical high endothelial venules was observed, also. He was treated by surgical excision of mass, systemic steroid therapy, and focal radiotherapy. During the follow-up of 3 years, the lesion was not recurred and no proteinuria, decreased serum eosinophilia and serum Ig E were noted in laboratory test. We experienced the treatment of huge sized Kimura's disease without recurrence and a case is presented with the review of literature.

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