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J Breast Cancer. 2016 Sep;19(3):324-329. English. Case Report. https://doi.org/10.4048/jbc.2016.19.3.324
Ricciuti B , Leonardi GC , Ravaioli N , De Giglio A , Brambilla M , Prosperi E , Ribacchi F , Meacci M , Crinò L , Maiettini D , Chiari R , Metro G .
Department of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy. biagio.ricciuti@gmail.com
Department of Experimental Medicine and Biochemical Sciences, Section of Anatomic Pathology and Histology, University of Perugia, Perugia, Italy.
Department of Diagnostic Cytology and Histology Unit, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.
Department of Diagnostic Imaging, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.
Abstract

Breast cancer metastases to the gastrointestinal tract are very rare occurrences. Among the histological subtypes of breast cancer, invasive lobular carcinomas have a high capacity of metastasis to uncommon sites including the stomach. Conversely, there has not been sufficient evidence supporting the gastric metastasis of invasive ductal carcinoma. Herein, we report a unique case of metastatic ductal breast carcinoma mimicking primary linitis plastica in a male patient, particularly focusing on the clinical and pathological features of presentation. Moreover, we propose a immunohistochemical panel of selected antibodies including those for cytokeratin 20, cytokeratin 7, estrogen receptor, progesterone receptor, E-cadherin, gross cystic disease fluid protein 15, and GATA binding protein 3 for an accurate differential diagnosis.

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