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J Breast Cancer. 2016 Jun;19(2):218-221. English. Case Report.
Maeshima Y , Oseto K , Katsuragi R , Yoshimoto Y , Takahara S , Yamauchi A .
Department of Breast Surgery, Kitano Hospital Breast Center, The Tazuke Kohukai Medical Research Institute, Osaka, Japan.

Women with BRCA1/2 mutations have a high risk of breast cancer and may opt for risk-reducing mastectomy (RRM). We report a 38-year-old Japanese woman who was diagnosed as a BRCA2 mutation carrier. She underwent prophylactic bilateral skin-sparing mastectomy (SSM) with excision of the nipple and preservation of the areola skin. It is unclear whether a bilateral RRM leads to better survival compared with intensive surveillance. The oncological risk associated with the presence of remnant breast glandular tissue after SSM or nipple-sparing mastectomy has been obscure. We report the first case of RRM for a Japanese BRCA mutation carrier and provide a literature review on risk management for BRCA mutation carriers with a focus on the concepts and procedures of RRM.

Copyright © 2019. Korean Association of Medical Journal Editors.