PURPOSE: The purpose of this study was to examine the effects of family function, self-esteem, and loneliness on subjective health status in middle-aged women. METHODS: A five-item family APGAR was used to measure family function. Self-esteem was measured by the Rosenberg's Self-esteem scale, and the level of loneliness was measured using RULS. One-item was used to investigate subjective health status. RESULT: In this study, the level of family function was moderate. The mean score of self-esteem was 29.06, and subjects revealed moderate loneliness. Subjects rated their health status as 'fair'. There were differences in subjective health status according to education and economic status. Through multiple regression, it was found that self-esteem was a variable predicting subjective health status in middle-aged women. CONCLUSION: Facilitating self-esteem of the middle-aged women can be one of the important nursing interventions in maintaining subjective health status as good.