This study was designed to identify the relationship between the perceived burden that is felt by family caregivers of hemodialysis patients and the quality of life of these caregivers. The subjects for this study were 102 family caregivers of patients who received hemodialysis regularly in the hemodialysis units of 4 hospitals located in Chonbuk. The data was collected during the period from February 17 to March 28, 1997 through interviews and by distributing a structured questionnaire to family caregivers through hemodialysis patients, and by mail service. The instruments used for this study are as follows : The burden instrument was the Burden Questionnaire developed by Lee Sook-Ja by referring to the Burden Scale developed by Novak & Guest(1989) and Zarit et al.(1980). The quality of life instrument was the Andrews' Scale that was treanslated and proof-read by Jeong Chu-Ja and partially amended by the author of this study. The collected data was analyzed by descriptive statistics, ANOVA, the Scheff test, Pearson's correlation and Stepwise Multiple Regression using the SAS PC+ program. The results of this study are as follow : 1. Hypothesis 1 : "The higher the perceived burden, the lower the quality of life of family caregivers of hemodialysis patients" was supported(r=-0.463, p=.000). 2. Hypothesis 2 : "The burden of family caregivers of hemodialysis patients will differ depending on the demographic characteristics of hemodialysis patients and family caregivers" was partially supported-age of family caregiver(F=3.04, p=.020), educational level of family caregiver(F=3.81, p=.012), marital status of family caregiver(F=5.82, p=.004), relationship with hemodialysis patient(F=2.74, p=.016), sex of hemodialysis patient(F=6.79, p=.010). 3. Hypothesis 3 : "The quality of life family caregivers of hemodialysis patients will differ depending on the demographic characteristics of hemodialysis patients and family caregivers" was partially supported-age of family caregiver(F=2.82, p=.029), educational level of family caregiver(F=4.64, p=.004), marital status of family caregiver(F=6.62, p=.002), monthly total income of family(F=5.61, p=.001), age of hemodialysis patient (F=3.42, p=.011), occupation change of hemodialysis patient(F=3.54, p=.032). 4. Stepwise Multiple Regression Analysis indicated that the six variables-the perceived burden of family caregiver, monthly total income of family, religion of family caregiver, occupation of family caregiver, marital status of hemodialysis patient, education level of family caregiver-were significantly predictive of the quality of life of family caregivers of hemodialysis patients. The six variables explained 41.7% of the variance in quality of life. In conclusion, this study revealed that the perceived burden is an important factor related to the quality of life of family caregivers of hemodialysis patients. Therefore, nurses must recognize family caregivers as well as hemodialysis patients as important care receivers and incorporate an intervening plan that reduces the burden and promotes the quality of life, taking into account the demographic characteristics of hemodialysis patients and their family caregivers.