This study was designed to test the correlation between spiritual well-being and quality of life and to identify this variable on quality of life. The subjects were 70 cancer patients of select hospitals in Seoul. Ellison(1983)'s spiritual well-being scale, Padilla's quality of life scale were used after some modification. The results & conclusions are as follows : 1. The score on the spiritual well-being scale ranged from 47 to 120 with a mean of 81.40(SD : 13.98). 2. The score on the quality of life scale ranged from 72 to 166 with a mean of 119.67(SD : 21.71). 3. In the relationship between social-demographic & spiritual well-being were significant difference in religion, the degree of faith & education. 4. There were significant correlations between spiritual well-being and quality of life. (gamma=.584, P<.001) 5. Existential spiritual well-being had significant effect on quality of life.(37%) In conclusion, the results propose the processes from spiritual well-being to quality of Life through religion. Spiritual well-being intervention programs are needed to improve the quality of life in cancer patients.