Iron deficiency anemia is still a common pediatric hematologic disease in the world. First line treatment for iron deficiency anemia is oral iron supplementation. However, some children need parenteral iron therapy either because they cannot receive oral iron or because they do not respond to it. We used intravenous iron sucrose for three children with iron deficiency anemia who did not respond to oral iron. All were successfully treated without any significant adverse effects. Since studies about effects and adverse effects of intravenous iron sucrose on pediatric patients with iron deficiency anemia are limited, further studies are needed.