STUDY DESIGN: The authors employed a new mode of treatment for the tuberculosis of the lower lumbar spine that has difficulty in using pedicle screws. SUMMARY OF LITERATURE REVIEW: It has been reported that patients ended up with a kyphosis had a higher incidence of back pain. OBJECTIVES: The purpose of this study is to evaluate the efficacy of the method consisting of posterior instrumentation with compressive laminar hooks and anterior lumbar interbody fusion. MATERIALS AND METHODS: Twenty-one patients with tuberculosis of lower lumbar spine underwent posterior instrumentation with laminar hooks and anterior interbody fusion by a single surgeon. The clinical outcomes were evaluated and the radiographs were analyzed with respect to fusion status and sagittal angle. RESULTS: A solid bony fusion was obtained in all patients. The preoperative, immediate postoperative, and follow-up sagittal angles were -4.8 degree(range; from 2 degreeto -10 degree, SD = +/-4.1 degree), -14 degree(range; from -10 degreeto -18 degree, SD = +/-3.3 degree), and -11.3 degree(range; from -6 degree to -15 degree, SD = +/-4.1 degree), respectively. There is no complication related to the instrument, but one patient suffered a tear of inferior vena cava during the operation. CONCLUSIONS: This method appears to be effective in stabilizing the vertebrae without sacrificing additional motion segment. We would recommend this method for tuberculosis of lower lumbar spine.