STATEMENT OF PROBLEM: It has been proved that Pleurotus eryngii Quel and Eleutherococcus senticosus have antiinflammatory action and not only stimulates the proliferation and activity of osteoblast but inhibits the generation and activity of osteoclast in vitro. Pleurotus eryngii Quel and Eleutherococcus senticosus are the main component of OPB-K(R). PURPOSE: The purpose of this study was to evaluate OPB-K(R) which enhances the healing rate of peri-implant bone and the bone mineral density. MATERIALS AND METHODS: Thirty six specially designed implants were installed in the tibia of rats. The group medicated with OPB-K(R) was the experimental group, and that without was the control group. hen the implant stability was measured by Periotest(R). Bone mineral density and histological measurement were conducted at the 2nd, 4th and 6th week Periotest(R) and bone mineral density values were analyzed statistically with independent t-test at 95% confidence level(P<0.05). RESULTS: The results of this study were as follows : 1. There was no statistically significant difference in Periotest(R) values between the experimental group and control group at the 2nd week, however, on the 4th and 6th week there was significant difference(P<0.05). 2. There was no statistically significant difference in bone mineral density between the experimental group and control group at the 2nd and 4th week, however on the 6th week there was significant difference(P<0.05). 3. Histological analysis showed difference in osseointegration on the 4th and 6th week between the groups. CONCLUSION: From the results, it is concluded that the OPB-K(R) medicated group showed statistically better results in bone density and stability than the control group. Clinically it would be better to medicate OPB-K(R) to patients for a long period of time after implantation to get superior results.