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J Korean Soc Transplant. 2014 Dec;28(4):241-245. Korean. Case Report.
Lee KH , Kim HS , Yun SH , Lee JH , Oh JS , Kim SM , Sin YH , Kim JK .
Division of Nephrology, Department of Internal Medicine, Bong Seng Memorial Hospital, Busan, Korea.

Tuberous sclerosis complex (TSC) is a neurocutaneous disease characterized by the formation of hamartomas in multiple organs. TSC can show lesions including facial angiofibroma, shagreen patch on the skin, cortical tuber, subependymal nodule, astrocytoma in the brain, cardiac rhabdomyoma, and renal angiomyolipoma. In particular, renal angiomyolipoma may be a cause of end-stage renal disease (ESRD). On the other hand, sirolimus has regulatory effects on cellular growth and proliferation via its inhibitory effect on a protein, mammalian target of rapamycin. We report on a case of an 18-year-old male who underwent renal transplantation due to ESRD induced by TSC. Sirolimus played a role in successful treatment of TSC and effective immunosuppression for transplantation.

Copyright © 2019. Korean Association of Medical Journal Editors.