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J Bacteriol Virol. 2014 Mar;44(1):112-114. English. Letter. https://doi.org/10.4167/jbv.2014.44.1.112
Manzoor Z , Koh YS .
Department of Microbiology and Immunology, Jeju National University School of Medicine, Jeju, Korea. yskoh7@jejunu.ac.kr
Abstract

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that plays an important role in innate immunity. Transfection of DNA or DNA virus infection results in the induction of type I interferon production in fibroblasts, macrophages, and dendritic cells which is dependent on cGAS. Recently, cGas (-/-) mice have been reported to be more vulnerable to fatal infection with herpes simplex virus 1 (HSV1) as compared to wild-type mice.

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