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J Bacteriol Virol. 2013 Dec;43(4):297-306. English. Original Article. https://doi.org/10.4167/jbv.2013.43.4.297
Kwon Y , Kim J , Kim JH , Hwang ES .
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea. hesss@snu.ac.kr
BK21 Plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, Korea.
Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Korea.
Abstract

p53 is a well-known multi-functional transcription regulator and is critical in the induction of apoptosis in response to various stresses. Human cytomegalovirus (HCMV) infection induced the accumulation of p53, which was partly relocalized in cytoplasm, but no apparent cell death in human fibroblasts. p53 in HCMV-infected cells was mainly mono-ubiquitinated, which might be resulted from the decreased expression of MDM2 in the course of HCMV infection. Ubiquitinated p53 was also phosphorylated at serine 20. CRM1 increased in the cytoplasm of HCMV-infected cells. It was found that p53 and its mutant in nuclear export sequences were localized in the cytoplasm of cells when co-expressed with CRM1. Collectively, our data suggest that HCMV infection modifies p53 into a stable and exportable form and accumulates it in the cytoplasm, but does not result in apoptotic death of cells.

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