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J Bacteriol Virol. 2013 Dec;43(4):270-278. English. Original Article.
Dang HT , Kim SA , Park HK , Shin JW , Park SG , Kim W .
Department of Microbiology, College of Medicine, Chung-Ang University, Seoul, Korea.
Division of Pulmonology and Allergology, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.
Department of Applied Statistics, Faculty of Business and Economics, Chung-Ang University, Seoul, Korea.

Bronchial asthma can be triggered by microbial agents in the oropharynx. This study was designed to identify the differences in microbiota of oropharynx of bronchial asthmatic patients in contrast to normal controls. In order to resolve the qualitative and quantitative diversity of the 16S rRNA gene present in the oropharynx microbiota of 4 patients and 4 controls, we compared microbial communities using Sanger sequencing and 376 sequences of 16S rRNA gene were analyzed. Of the total microbial diversity detected in the oropharynx in asthmatic patients 45.6% comprised members of the Firmicutes. In contrast, Proteobacteria (44.0%) dominated the oropharyngeal microbiota in the normal control group. Members of the Bacteroidetes, Fusobacteria, Actinobacteria, TM7, Cyanobacteria and unclassified bacteria were present in both groups. In conclusion, the difference in the microbiota of the oropharynx between patients and normal individuals could trigger symptomatic attacks in bronchial asthma.

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