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J Bacteriol Virol. 2013 Sep;43(3):233-234. Korean. Letter. https://doi.org/10.4167/jbv.2013.43.3.233
Kwon EJ , Koh YS .
Jeju National University School of Medicine, Jeju, Korea. yskoh7@jejunu.ac.kr
Abstract

Anticancer drugs kill tumor cells and increase host anti-tumor immunity. Interestingly, gemcitabin (Gem) and 5-fluorouracil (5-FU), widely used anticancer drugs, lead to IL-1beta secretion releasing cathepsin B which activates Nlrp3 inflammasome in myeloid derived suppressor cells (MDSCs). MDSC derived IL-1beta enhance secretion of IL-17 by CD4+ T cells. This mechanism limits the antitumor efficacy of the drugs and promotes tumor growth.

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