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J Bacteriol Virol. 2006 Jun;36(2):51-57. English. Original Article.
Kim MK , Kim MJ , Lim BU , Kang JS .
Department of Microbiology, Inha University College of Medicine, Incheon 400-712, Republic of Korea.
Inha Research Institute for Medical Sciences, Incheon 400-712, Republic of Korea.

Microtubule network provides many intracellular microbes with an efficient way to move within host cells. Orientia tsutsugamushi move from the cell periphery to the microtubule organizing center (MTOC) by dynein-dependent mechanism. In this study, we investigated the role of microtubule on the growth of O. tsutsugamushi. The treatment of infected cells with taxol as well as daunomycin enhanced the bacterial growth in contrast to colchicine. Immunofluorescent (IF) staining of taxol-treated cells exhibited that O. tsutsugamushi clustered tightly near the nucleus with thick bundles of microtubules, whereas dispersed in the cytoplasm in colchicine-treated cells. These results suggest that microtubule network facilitate the growth of O. tsutsugamushi.

Copyright © 2019. Korean Association of Medical Journal Editors.