PURPOSE: Several studies and papers have reported good short-term results for using 120W HPS laser PVP. Here we report the short-term and long-term clinical outcomes analysis with efficacy and safety of 120W HPS laser PVP for the treatment of BPH. MATERIALS AND METHODS: We performed a retrospective clinical analysis of 357 patients, who underwent 120W HPS laser PVP for the treatment of BPH from April, 2009 to Feb. 2011. The IPSS, Qmax and PVR values were evaluated preoperatively and postoperatively. RESULTS: The mean age at the surgery; 70.35+/-8.28, mean prostate size; 46.56+/-21.11 ml, and mean PSA was 4.16+/-4.35 ng/ml. Mean operation time was 41.8+/-34.1 min, and mean lasing time was 19.8+/-11.3 min. Mean applied energy was 134,294.9+/-225,211.5 J. Thirty cases of co-operation were done. Mean catheter indwelling time was 0.84+/-0.36 day, and mean hospital stay was 1.1+/-0.2 day. The blood loss was minimal so transfusions were not needed. The baseline IPSS-sum; 19.61+/-9.13, QoL score; 4.28+/-1.02, Qmax; 7.94+/-5.51 ml/sec, PVR; 101.62+/-102.58 ml, At 1 month, IPSS-sum; 8.64+/-7.34, QoL score; 2.19+/-1.48, Qmax; 13.32+/-8.94 ml/sec, PVR; 32.54+/-46.07 ml was noted. At 12 months, IPSS-sum; 8.33+/-5.04, QoL score; 1.33+/-1.08, Qmax; 15.75+/-2.90 ml/sec, PVR; 21.56+/-31.28 ml was noted. Within 1 month of operation, 18 cases of dysuria and 27 cases of retention were reported but these were resolved with medication and observation. Compared with preoperative values, there were statistical improvements after the operation. CONCLUSIONS: 120W HPS laser showed statistical improvements after 1 month operation and these results were sustained for 12 months. Although limitations, our long term experience suggest that significant improvements in symptomatic and urodynamic outcomes of 120W HPS laser PVP.