Botulinum toxin type A is a polypeptide neurotoxin derived from the anaerobic bacterium Clostridium botulinum. Safe and effective Botulinum type A toxin has found clinical application as a treatment for strabismus, blepharospasm, palmar hyperhidrosis. Now this toxin is widely used for improving the facial rhytides cosmetically. Author applicated this toxin not only for facial rejuvenation but also for improving for masseter muscle hypertrophy, facial asymmetries after orthognathic surgery, dysmorphis caused by facial nerve paralysis, TMD and habitual TMJ luxation. Author report clinical results with literature review.