Ameloblastic fibroodontoma is a mixed odontogenic tumor in very rare occurrence that is composed of proliferating ectodermal mesenchymal component of odontogenic tissues such as enamel and dentin. Its frequency is about 2 percents of all odontogenic tumors, and it usually does not lead to pain. Therefore, it may be unexpectedly detected on gradual facial asymmetry or examination of unerupted tooth. And displacement of teeth have also been frequently reported. Most of ameloblastic fibroodontomas develop in average age of 10 years and rarely occurs in older person. The difference between sexes is similar, and are equally affected on maxilla and mandible, posterior prevalence is also showed. First case is unexpectedly detected in a 17 years-old male on examination of unerupted tooth and the second case is developed in a 13 years-old female who showed an asymptomatic swelling of left midfacial area. Each patient is tentatively diagnosed as a ameloblastic fibroodontoma and a benign tumor. Surgical enucleation under general anesthesia was performed. The postoperative histologic diagnosis was ameloblastic fibroodontomas. No recurrences and good healing were showed during follow up period of 4 and 3 years from the enucleation of the tumor. Now we present two cases of ameloblastic fibroodontoma with differential diagnosis and immunohistochemical characteristics.