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J Asthma Allergy Clin Immunol. 2003 Sep;23(3):467-473. Korean. Original Article.
Jin HR , Sohn B , Zhe YX , Kim YS , Jung SH , Lee SH , Ryu JC , Kim MK .
Department of Otorhinolaryngology, Chungbuk National University, Cheongjoo, Korea.
Department of Diagnostic Pathology, Chungbuk National University, Cheongjoo, Korea.
Department of Internal Medicine, College of medicine and Medical Research Institute, Chungbuk National University Cheongjoo, Korea.
College of Pharmacy, Chungbuk National University, Cheongjoo, Korea.
College of Pharmacy, Chungnam National University, Daejeon, Korea.
College of Pharmacy, Yeungnam University Daegu, Korea.
Toxicology laboratory Korean Institute of Science and Technology, Seoul, Korea.

BACKGROUND: Infiltration of eosinophils in the nasal mucosa is a consistent feature of nasal allergic inflammation. Various cytokines, especially interleukin-5(IL-5), were identified to play important roles in the infiltration and activation of eosinophils in nasal mucosa. Our previous study found that among 4 kinds of sophoricosides extracted from Sophora japonica, named sophi, orobol, genistin, and genistein, 3 compounds except genistein known as protein tyrosine kinase(PTK) inhibitor had anti-inflammatory and anti-IL-5 effects, and sophi was the most potent. OBJECTIVE: The goal of this study was to investigate the antagonism of sophi on the nasal eosinophilia in ovalbumin(OA)-sensitized murine nasal allergy model. METHODS: Male BALB/c mice sensitized intraperitoneally and then topically with OA were treated with sophi(10 or 30mg/kg) or anti-mouse IL-5 monoclonal antibody(anti-IL-5 mAb, 1mg/Kg) intravenously 1 hour before challenge. The effect of sophi on the infiltration of eosinophils into the nasal mucosa, peripheral blood eosinophilia, nasal symptom, and OA-specific IgE antibody production were evaluated. Results: Administration of sophi(10, 30mg/kg) significantly inhibited the nasal eosinophil infiltration and nasal symptom compared to that of anti-IL-5 mAb. But eosinophil count inthe peripheral blood and the titer of OA-specific IgE were not affected by sophi. CONCLUSION: Sophi inhibited not only the tissue eosinophilia but also the acute nasal allergic symptom. These findings suggest that sophi has anti-eosinophilic cytokine activity and also plays blockade of early allergic reaction. Taken together, sophi may be a candidate for new anti-allergic medicine.

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