BACKGROUND AND AIM: Allergic skin test and serum specific IgE are major tools in the diagnosis of atopy. Many factors influence the results of those two studies. We evaluated the correlation between the responses of allergic skin test and the level of specific IgE as related aging process. METHODS: 234 atopic asthma patients were enrolled and divided into 3 different groups according to their ages. All subjects were performed allergic skin test and measured serum specific IgE. We used only two common antigens, D. farinae and D. pteronyssinus. RESULTS: Positive rates on allergy skin prick test and serum specific IgE reduced as increasing of subject's ages with showing significant agreement rates of results of both tests among 3 different age groups. CONCLUSION: The aging process may make, not only decrease of the specific cutaneous responses, but decrease of the production of antibodies, and immunologic activities itself.