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Chonnam Med J. 1997 Jun;33(1):127-130. Korean. Original Article.
Kim MS , Kim JM , Kim JY , Park JH , Lee JH , Yang SW , Chung DJ , Chung MY , Lee TH .
Department of Internal Medicine, Chonnam University Medical School, Kwangju, Chonnam, Korea.

We studied the acute effects of cigarette smoking on glucose tolerance, heart rate and blood pressure in smoker and non-smoker group. Two 75-gram oral glucose tolerance tests (OGTT) were performed in 6 healthy smokers and 6 non-smokers at an interval of one week. The subjects smoked one cigarette at each time period of 0, 15, 30 min during the second OGTT. Serum glucose, insulin, and C-peptide levels measured every 30 min and blood pressure with heart rate every 10 min for 120 min during 75 g OGTT. The results are follows 1) In non-smokers, serum glucose and insulin levels showed an increased tendency at 30 min during smoking OGTT comparison to control OGTT. C-peptide level at 30 min during smoking OGTT was 12.1+/-6.2 microIU/microliter, which was significantly higher than that during control OGTT (7.5+/-2.9 microIU/microliter) in non-smokers (p<0.05). 2) In non-smokers, systolic blood pressure during smoking OGTT was 123+/-8.0, 130+/-7.8, 127+/-7.5, 130+/-7.6 mmHg respectively at 10, 20, 30, 40min, while systolic BP during control OGTT was 114+/-3.4, 114+/-7.9, 115+/-8.2, 115+/-6.4 mmHg (p<0.05). 3) In smokers, there were no significant difference in blood sugar, insulin, and C-peptide levels between control and smoking OGTT. But heart rate from 10 to 60min and systolic pressure from 20 to 40 min during smoking OGTT were significantly increased (p<0.05). 4.6, 110+/-6.2 mmHg during control OGTT respectively (p<0.05). Above results suggest that smoking acutely induces a transient hyperinsulinemia with glucose intolerance, and is related to insulin resistance.

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