Because of decreased host immunity, poorly controlled diabetic patients are susceptible to infections of the urinary tract, respiratory tract and skin, etc. Although the source of the liver abscess was not found frequently, diabetes mellitus was a frequent underlying condition. Although a relationship between pyogenic liver abscess and diabetes has not been proved, it has been suggested that persons with diabetes have a defect in host-defense mechanisms that make them more susceptible to the development of pyogenic liver abscess. While drainage-either percutaneous with pigtail catheter kept in place or surgical-remains the mainstay of therapy for liver abscesses, there is growing interest in medical management alone for pyogenic liver abscesses. We report a 72-year-old woman with NIDDM patient complicated with non-ketotic hyperosmolar coma. A blood culture grew K. pneumoniae. Ultrasonogram revealed about 10cm-sized abscess cavity and the chest PA revealed multiple septic emboli. She improved with medical treatment. Repeat Ultrasound showed a normal liver and chest PA was also normal.