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J Korean Neuropsychiatr Assoc. 2000 Sep;39(5):955-959. Korean. Case Report.
Chee IS , Park CB , Lee SW , Wang SK , Shin SC .
Department of Psychiatry, College of Medicine, Chungnam National University, Taejeon

Nocturnal enuresis has been recognized as an adverse effect of clozapine treatment. We reported 3 chronic schizophrenic patients who had showed nocturnal enuresis following clozapine treatment. Oxybutynin hydrochloride on clozapine-induced enuresis was very effective in 3 patients. The dose in our patients was 5 to 10mg/day. This medication was well tolerated. It is suggested that oxybutynin hydrochloride is a effective therapeutic option in clozapine-induced nocturnal enuresis.

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