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Korean J Anat. 2007 Jun;40(2):107-113. English. Original Article.
Jung YW , Park JS .
Department of Anatomy, College of Medicine, Dongguk University, Kyungju 780-714, Korea.

We conducted a chronological and comparative analysis of the levels of the electrogenic Na+/HCO3-cotransporter (eNBC) and Na+/H+ exchanger 1 (NHE1) on ischemic penumbra, using the rat model of permanent middle cerebral artery occlusion (pMCAO). Both eNBC and NHE1 levels were significantly higher in the ischemic penumbra from 3 h to 6 h after focal ischemia than in the sham-operated control group. The enhancement of eNBC and NHE1 production following focal ischemia may contribute to brain cell swelling or damage during ischemic penumbra through intracellular alkalinization and Na+ overload. Therefore, increases of eNBC and NHE1 in ischemic penumbra may play an important role in secondary brain cell damages following permanent focal ischemic insults.

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