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Korean J Anat. 2002 Feb;35(1):91-97. Korean. Original Article.
Yang YM , Lee WK , Jin KS , Lee YI , Kim DS , Yoo HD , Ahn HK .
Department of Anatomy, College of Medicine Kyunghee University, Korea. hakbeom@hananet.net
Department of Anatomy, Gachon Medical School, Korea.
Department of Preventive Medicine, Gachon Medical School, Korea.
Department of Dermatology, College of Medicine Kyunghee University, Korea.
Abstract

Tenascin is suggested the one of cause of vitiligo by interfering melanocyte adhesion and migration. The distribution and expression levels of tenascin were examined by semiquantitative immunohistochemistry on skin biopsies from vitiligo patients with varying area of photodamage. The level of tenascin on adult skin is severely restricted but we had observed the increase on vitiligo skin lesions. Although it is uncertain that the increased tenascin expression is the cause or the result of disease, vitiligo and increased tenascin expression is thought to be related each other. This study has shown that tenascin increased on photodamaged vitiligo skin lesions. So we shoud consider choosing phototherapy to vitiligo.

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