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Korean J Anat. 2002 Feb;35(1):37-42. English. Original Article.
Chun HM , Kim JM , Lee YH .
Department of Anatomy, College of Medicine, Chungnam National University, Daejeon, Korea.
Department of Neurology, College of Medicine, Chungnam National University, Daejeon, Korea.

Status epilepticus (SE) can be induced with homocysteine after pretreatment with cobalt. In order to investigate the pattern of neuronal changes in the hippocampus in cobalt/homocysteine-induced SE, H-E staining and immunohistochemistry for c-Jun were performed in the brain after SE. Neuronal damage was not seen in the hippocampus in cobalt-treated control rats. Neuronal injury occurred in 14% of the cells in the hilus 24 hrs after SE. The neuronal injury was minimal in the dentate gyrus (DG), CA3, and CA1 24 hrs after SE. c-Jun immunoreactivity was detected strongly in the DG and CA3 2 hrs after SE, and then c-Jun immunoreactivity was decreased to that of control rats in the hippocampus 24 hrs after SE. These results suggest that upregulation of c-Jun expression in the hippocampus is not related to neuronal death in cobalt/homocysteine-induced SE, secondary generalized epilepsy originating from the cerebral cortex does not cause significant hippocampal cell injury.

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