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Korean J Dermatol. 2014 Jan;52(1):1-6. Korean. Original Article.
Choi KH , Lee YS , Yoon JH , Yoo WK , Kim MR , Lee KS , Cho JW .
Department of Dermatology, Keimyung University School of Medicine, Daegu, Korea.
Research Institute of Korea Horse Industry, Sung Duck University, Yeongcheon, Korea.
Department of Health Science, Daegu Haany University, Daegu, Korea.
Department of Herbal Pharmacology, College of Oriental Medicine, Daegu Haany University, Daegu, Korea.

BACKGROUND: Anti-inflammation, anti-bactericidal, and collagen synthesis are important for health skin conditions. However, the effect of horse oil on anti-inflammation, anti-bactericidal, and collagen synthesis is largely unknown. OBJECTIVE: The aim of this study was to evaluate the anti-bactericidal, anti-inflammatory, and synthesis of type I collagen of horse oil. METHODS: Anti-bacterial effect was evaluated by disc diffusion test. Expressions of inflammatory cytokines were studied by RT-PCR analysis, real time PCR. Type I collagen expression was evaluated by Western blot in human HaCaT kertinocytes and fibroblasts. RESULTS: Our data showed that horse oil exerted anti-bacterial effect on P.acnes and S.aureus. Expression of IL-10 was increased by horse oil-treated HaCaT cells. In addition, increased expression of type I collagen was observed in horse oil-treated human skin fibroblasts. CONCLUSION: Horse oil exerts an anti-bactericidal effect against P.acnes and S.aureus. In addition, anti-inflammatory and anti-aging effects of horse oil will be mediated by up-regulation of IL-10 and type I collagen, respectively.

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