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Korean J Crit Care Med. 2015 May;30(2):103-108. English. Case Report.
Lee HY , Lee HY , Shin SB , Shin KS , Lee BW , Kim HW , Lee S , Kim SC .
Division of Respiratory, Allergy and Critical Care, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Thoracic and Cardiovascular Surgery, St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
Division of Hematology and Oncology, Catholic Blood and Marrow Transplantation Center, Department of Internal Medicine, St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

Colonization of the pre-transplant lung by multidrug-resistant bacteria affects short- and long-term outcomes of lung transplantation. However, there are no case reports on the colonization of a pre-transplant lung by drug-resistant Acinetobacter baumannii. We report a case of extensively drug resistant (XDR) A. baumannii colonization in the tracheobronchial tree that caused severe infectious complications after bilateral lung transplantation. A 23-year-old man diagnosed with bronchiolitis obliterans syndrome (BOS) 4 years earlier with a history of allogenic bone marrow transplantation for acute lymphoblastic leukemia was admitted to the hospital with dyspnea. Due to progressive hypercapnic respiratory failure, long-term mechanical ventilation was started after a tracheostomy was performed, and the patient underwent a bilateral lung transplantation to treat end-stage BOS. After the transplantation, the colonization of XDR A. baumannii caused severe bacterial pneumonia in the early postoperative period. Combined treatment with colistin and meropenem led to recovery from the pneumonia but caused drug-induced renal failure. Because many centers are willing to transplant candidates who are on mechanical ventilation or extracorporeal life support, the incidence of XDR A. baumannii colonization of pretransplant lungs is expected to increase. Further studies are needed to examine pre-transplant management strategies in patients colonized with XDR A. baumannii.

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