OBJECTIVE: Neonatal respiratory distress syndrome (RDS) occurs in preterm infants, due to structural immaturity of the lungs and immaturity of the pulmonary surfactant metabolism and activation of inflammation and clotting contribute to the development of bronchopulmonary dysplasia (BPD). The purpose of this study is to evaluate the influencing factors in the development of BPD among RDS infants with coagulation disorder. METHODS: A retrospective chart review for 49 premature infants who were admitted to Pochun CHA University neonatal intensive care unit between May 2001 and July 2003. Infants with a gestational age <32 weeks or birth weight <1,500 g who had RDS and coagulation disorder were included in this study. Infants were divided into two groups, 22 infants in the BPD group and 27 infants in the Control group. And we evaluated the perinatal, clinical and bleeding manifestations and laboratory finding of 1st, 3rd, 6th days after coagulation disorder occurred. RESULT: The incidence of pregnancy induced hypertension was higher in the control group. Birth weight and gestational age were lower in the BPD group. Duration of ventilatory support and total parenteral nutrition were longer and the incidence of sepsis was higher in the BPD group. No significant difference was observed in laboratory finding when coagulation disorder occurred. CONCLUSION: Laboratory finding of premature when coagulation disorder occurred, was not associated with the prevalence of BPD, The compound effects of other risk factors may be important in the development of BPD.