We experienced musculoskeletal pain by somatization symptom and steroid myopathy in Cushing syndrome (adrenal adenoma) and hereby report this case. A 53-year old woman visited to clinic with chief complain of severe sole pain and tingling sensation (VAS 8.0) and multiple arthralgia (VAS 6.0) since 3 years ago. On examination, she showed severe depressive mood disorder, weakness of proximal limbs and other features of Cushing syndrome. The electromyelographic findings showed atypical type of myopathy without peripheral polyneuropathy. On laboratory examination, overnight and low dose dexamethasone suppression test was positive. The adrenal CT showed finding of left adrenal adenoma. After diagnosed of Cushing syndrome, laparoscopic adrenalectomy was done. The patient's severe pain and tingling sensation were immediately improved (VAS 3.0) concurrently with improvement of depressive mood following surgery. We concluded that the pain was originated from somatization symptom.