Running is becoming one of the most popular leisure sports. Part of the growing popularity of running is its easy accessibility and health benefits. The incidence of running injuries rates ranges from 37% to 56%, which incidence rate is still 2 to 6 times lower than in all other sports. Most running injuries are musculoskeletal overuse syndrome of the lower extremity. The risk factors of running injuries can be training errors, improper running surface, worn shoes, body flexibility, prior injury. The knee is the most common site of injury and accouts for 25% to 33% of all, and pa-tellofemoral stress syndrome is the most common known as runner's knee. Iliotibial band syndrome, medial tibial stress syndrome, plantar fascitis, Achilles tendinitis, stress fracture are common injuries in runners. The physical examination includes a biomechanical screening to identify related imbalances. Additionally, each runner is observed walking and running. This comprehensive, running specific approach to diagnosis can be helpful in developing optimum rehabilitation program.