PURPOSE: Combined organ resection is a common operation in gastric cancer surgery. The aim of this study is to investigate the risk of combined minor organ resection (GB, gynecologic organ, appendix etc) in gastric cancer surgery. METHODS: The clinical data from 673 consecutive patients who underwent gastrectomy for gastric cancer at a single center were retrospectively analyzed. We investigated clinical data between open groups (OG) and laparoscopy groups (LAG), and we divided the patients into 3 groups: no resection group, minor organ resection group and major organ (spleen, pancreas, and colon) resection group. RESULTS: There were higher complication rates in major organ resection group (59.3%, 53.8%) than no resection (32.3%, 19.1%) or minor organ resection groups (38.7%, 20%) both in OG and LAG (P<0.05). However, there were longer hospital stays in minor (22.2 days) and major resection groups (24.1) than no resection group (16.2) in OG, but stays were longer in major resection group (30.9) than minor (14.5) and no resection group (16.2) in LAG (P<0.01). Operative times were longer in minor (287 min) and major organ resection group (310) than no resection group (243) in OG (P<0.00). However, operation time was longer in major resection group (505) than minor (415) and no resection group (370) in LAG (P=0.00). CONCLUSION: Combined minor organ resection with gastrectomy does not increase morbidity, and there is no statistical difference in hospital stay and op time than no resection group in LAG.