Most intussusceptions occur in children and no etiologic factor can be determined in most cases. In contrast, adult intussusception is rare and many cases in adults are generally related to neoplasm such as lymphoma, carcinoid tumor, malignant tumor, sarcoma, benign tumor and congenital abnormalities. Intussusception in adults that's due to primary malignant lymphoma of the terminal ileum is a rare clinical condition. We describe here two cases of ileo- colonic-type intussusception that were due to primary malignant lymphoma of the terminal ileum. The clinical, radiographic and pathologic finding are described along with a brief review of the literature.