Squamous cell carcinoma of the pancreas is a rare variant of pancreatic ductal cell carcinoma. Its biologic behavior and clinical features are known to be similar to the much more common ductal adenocarcinoma of pancreas. A 70-year old man with postprandial vomiting symptom was admitted to our hospital. Initial endoscopy and abdominal CT showed that 6cm sized submucosal tumor on pylous or duodenum invaded the pancreas. Subtotal gastrectomy with partial pancreatic resection was done. The resection specimen revealed of metastatic squamous carcinoma of stomach and duodenum. Follow up CT was revealed that multiple liver metastasis and a large mass in peripancreatic space. The mass was confirmed invasive squamous cell carcinoma of pancreas by aspiration biopsy. The patient died of cancer cachexia 50 days after operation. We report an unusual case of squamous cell carcinoma of the pancreas which was invaded to duodenum and pylorus with a review of literature.