Purpose: Generally, morbid obesity has accompany with co-morbidities including dyslipidemia. Bariatric operation has shown various degree of effectiveness and different mechanism on weihgt loss. The effectiveness of sleeve gastrectomy in lipid profile is not revealed until now. Therefore, we have investigated and evaluated the efficacy of sleeve gastrectomy on weight loss and serum lipid profile. METHODS: We retrospectively reviewed 42 patients who underwent laparoscopic sleeve gastrectomy. All the patient was divided into two groups (group A (n=35): >50% excessive weight loss (EWL) in 6 months postoperatively, and group B (n=7): <50% (EWL)). Anthropometric Indices and serum lipid profile were measured before sleeve gastrectomy and postoperatively in 6 months. RESULTS: EWL of all the patients was 74.1+/-21.9% in 6 months postoperatively, group A was 80.4+/-18.2%, group B was 39.7+/-6.4%. Waist circumference, hip circumference, percent of body fat and visceral fat area were decreased in group A than B (P <0.05). Especially the visceral fat area of group A was reduced (-38.6%). Significant reduction of atherogenic index and triglyceride was observed (P <0.001) and increment of HDL cholesterol (P <0.001) was observed in both Groups. The moderate reduction of total cholesterol was observed in group A (P <0.05) but in not group B. LDL cholesterol level was mildly decreased but not statistically significant (group A: P=0.82, group B: P=0.746). Conclusion: Isolated vertical sleeve gastrectomy in morbid obesity patients is a effective surgical procedure. It offers excellent results in weight loss, anthropometric Indices and lipid profiles in short period of time. Eventually, it reduces the risk of coronary disease.