We present a case of toxoplasma lymphadenitis diagnosed by histologic and serologic evaluation. A 40-year-old woman presented with a 4-month history of a unilateral cervical lymphadenopathy. An excisional biopsy specimen of the lymph node disclosed a toxoplasma cyst. Her IgG anti-Toxoplasma serotiter far exceeded the upper normal limit. Histological findings supporting a diagnosis of toxoplasmosis correlated with the results of serological studies. This report emphasizes the need for clinicians to consider toxoplasmosis in the differential diagnosis of lymphadenopathies in young patients with enlarged cervical lymph nodes and varying degrees of fatigue, malaise, cough, and fever.