The most common metastatic site of a hepatocellular carcinoma is the lung, followed by the adrenal gland, inferior vena cava, bone, diaphragm in that order. However hepatocellular carcinoma metastasizing to the brain is rare. Only 7 cases has been reported in Taiwan. A metastatic brain tumor was excised and a hepatocellular carcinoma was treated by a left lateral segmentectomy. Adjuvant chemotherapy (5-FU, adriamycin) was added, and carcinoma was followed up for 10 months without recurrence. Here report a case of hepatocellular carcinoma metastasizing to the brain. with a review of the relevant literature.