BACKGROUND: There has not been a comprehensive review to compare the international eligibility criteria for apheresis donation. This study assessed the international variations of the eligibility criteria for apheresis donors to help improve our national criteria for safer and more efficient screening of donors. METHODS: We reviewed the websites of the American Red Cross, Canadian Blood Service, Australian Red Cross Blood Service, New Zealand Blood Service, Japanese Red Cross Society, Hong Kong Red Cross (HKRC), Health Sciences Authority of Singapore and the National Blood Service of the UK (NBS) and the European Union (EU). Only those criteria that were different from ours were analyzed. RESULTS: A considerable number of differences were identified between the international criteria and our criteria. The lower age limit was 17~18 years and the upper limit were 50~69 years for plasma donation and 50~59 years for platelet donation. The regulations for donation frequency ranged from none to 12~57 times/year for plasma and none to 12~24 times/year for platelets. The donation interval for plasma and platelets was 1~4 weeks. A minimum hemoglobin level of 12.5 g/dL was used in most countries, excluding the HKRC (11.5 g/dL for women). The NBS and EU had criteria regarding the volume of donation. CONCLUSION: Different international eligibility criteria for apheresis donors are used according to the characteristics of each country. Thus, the compiled data from various countries will provide the basis to improve our national eligibility criteria for apheresis donors.