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Korean J Gastrointest Endosc. 2008 Oct;37(4):299-302. Korean. Case Report.
Cho SW , Park WI , Kim HY , Kim KJ , Yang US .
Division of Gastroenterology, Department of Internal Medicine, Bong Seng Memorial Hospital, Busan, Korea. sungwhanch@hanmail.net
Abstract

Primary malignant melanoma of the anorectum is rare, representing about 1% of all colorectal carcinoma and less than 1% of all melanomas. The most common symptom of malignant melanoma of the anorectum is anal bleeding and this is often misdiagnosed as hemorrhoids. A 72-year-old female patient was admitted due to intermittent anal bleeding for 6 months. Colonoscopic examination showed a large exophytic mass with an irregularly ulcerated and greenish-brown pigmentation on the anus and the examination also simultaneously showed a submucosal tumor-like lesion in the rectum that was located 5 cm from the anal verge. Light microscopy of the tumor revealed malignant melanocytes and the tumor cells reacted positively for immunohistochemical staining with S-100 protein and HMB-45. Distant metastasis to the brain was detected on brain MRI.

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